Enterotoxin Receptors

Guanylate cyclase-coupled receptors that bind bacterial ENTEROTOXINS, as well as the endogenous peptides guanylin and uroguanylin. Ligand binding stimulates production of CYCLIC GMP by EPITHELIAL CELLS of the intestinal lumen, altering barrier permeability and mucus secretion. Mutations in the gene (GUCY2C) encoding this receptor are associated with some cases of hereditary diarrhea (Diarrhea 6) and MECONIUM ILEUS.

Also Known As:

Receptors, Enterotoxin; Enterotoxin Receptor; Enterotoxin-Guanylin Receptor; Enterotoxin-Guanylin Receptors; GC-C Receptor; GC-C Receptors; Guanyl Cyclase-C Receptor; Guanyl Cyclase-C Receptors; Guanylin-Uroguanylin Receptor; Guanylin-Uroguanylin Receptors; Guanylyl Cyclase C; Heat-Stable Enterotoxin Receptor; Heat-Stable Enterotoxin Receptors; Receptor, Enterotoxin; Receptor, Guanyl Cyclase-C; Receptors, Guanyl Cyclase-C; Cyclase C, Guanylyl; Cyclase-C Receptors, Guanyl; Enterotoxin Guanylin Receptor; Enterotoxin Guanylin Receptors; Enterotoxin Receptor, Heat-Stable; Enterotoxin Receptors, Heat-Stable; GC C Receptor; GC C Receptors; Guanyl Cyclase C Receptor; Guanyl Cyclase C Receptors; Guanylin Uroguanylin Receptor; Guanylin Uroguanylin Receptors; Heat Stable Enterotoxin Receptor; Heat Stable Enterotoxin Receptors; Receptor, Enterotoxin-Guanylin; Receptor, GC-C; Receptor, Guanyl Cyclase C; Receptor, Guanylin-Uroguanylin; Receptor, Heat-Stable Enterotoxin; Receptors, Enterotoxin-Guanylin; Receptors, GC-C; Receptors, Guanyl Cyclase C; Receptors, Guanylin-Uroguanylin; Receptors, Heat-Stable Enterotoxin

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Lyases: 637
    - Phosphorus-Oxygen Lyases
      - Guanylate Cyclase: 692
        Guanylate Cyclase-Coupled Receptors: 35
        Enterotoxin Receptors: 145
Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Membrane Proteins: 10078
    - Cell Surface Receptors: 2125
      - Peptide Receptors: 1159
        Enterotoxin Receptors: 145
      - Guanylate Cyclase-Coupled Receptors: 35
        Enterotoxin Receptors: 145

Ozlem N Sever Selected Research

Ozlem N Sever Research Topics

Disease

Drug/Important Bio-Agent (IBA)

Therapy/Procedure